Defining the Prevalence of Molar Incisor Hypomineralization in Brazil

Abstract Objective: To define the prevalence of Molar Incisor Hypomineralization (MIH) in Brazil since the reports ranged from 2.5% to 40.2%. Material and Methods: We studied 407 children from 7 to 14 years of age. MIH was measured using the European Academy of Paediatric Dentistry criteria of 2003. Clinical data were collected by a calibrated dentist (Kappa=0.88) and included affected teeth and degree of MIH severity (mild/severe). Mild MIH cases were considered when the tooth presented demarcated opacity ≥ 1.0mm, without any loss of structure. While severe cases were defined by teeth in which loss of structure was present, or past or current lesion that required treatment, or presence of atypical restorations. In addition, published data (nine studies) reporting MIH in Brazilians were identified, and the heterogeneity of these studies was tested (I2 index/ p≤0.01). Results: In the original sample studied, the majority of patients were males (55.3%; n = 225), with an average age of 10.1 years (± 2.1 years). The prevalence of MIH in this group was 14.5% (59 affected in 407), and most of the affected teeth had a mild degree of alteration (77.4% or 202 in 261 teeth). Conclusion: A meta-analysis including nine published reports, and our original data showed that MIH prevalence in Brazil is 13.48 (95% CI, 8.66% -18.31%).

Association between TNFα - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis

Abstract Objectives To determine whether Tumor Necrosis Factor alpha (TNFα) -308 G/A polymorphism is associated with oral lichen planus (OLP). Material and Methods A systematic electronic search of the literature was conducted to identify all published studies on the association between TNFα -308 G/A polymorphism and OLP. All case-control studies evaluating the TNFα -308 G/A polymorphisms in OLP were selected. A meta-analysis of the studies that fulfilled the inclusion criteria was performed. Odds ratios (OR) with 95% confidence intervals (CI) were also calculated. Results Seven studies comprising 450 OLP cases and 867 controls were included in the meta-analysis. In the pooled analysis, TNFα -308 G/A polymorphism was associated with OLP with random effects and OR of 2.33 (95%CI=1.07-5.11; p=0.03), assuming a dominant mode of inheritance (AA+GA vs. GG). In the subgroup analysis by ethnicity, TNFα -308 G/A was associated with a significantly increased odds ratio of OLP in mixed ethnicity (OR=5.22; 95%CI=1.93-14.15; p=0.001), but not in Asians (OR=1.57; 95%CI=0.54-4.54; p=0.41) or Caucasians (OR=1.45; 95%CI=0.19-11.22; p=0.72). For subgroup analysis based on HCV (hepatitis C virus) infection status, significant increased risk of OLP was found among patients with mixed HCV infection status (OR=3.77; 95%CI=1.07-13.2; p=0.038), but not in patients without HCV infection (OR=2.09; 95%CI=0.63-6.91; p=0.22) and patients with HCV infection (OR=0.48; 95%CI=0.13-1.69; p=0.25). Conclusion Our results suggest that -308 G/A polymorphism in TNFα is a potential genetic marker for OLP.

Impact of Prosthetic Characteristics and Life Stress on Oral Health Related Quality of Life in Anterior Fixed Dental Prosthesis Treatment.

Aims: This cross-sectional study aimed to explore potential factors influencing oral health related quality of life (OHRQoL) in a Chinese population treated with anterior dentition fixed dental prosthesis (FDP). Study Design: Cross-sectional study. Place and Duration of Study: West China Hospital of Stomatology, Sichuan University, between December 2012 and May 2013. Methodology: According to the patient records in the dental hospitals, 1918 patients were initially selected and invited for a follow-up examination. After the selection, 987 participants were finally included and asked to complete a questionnaire which included three forms: Basic information, the Chinese version of Oral Health Impact Profile-14 items (OHIP-14) and Social Readjustment Rating Scale (SRRS). After data collection, independent sample t-test, one-way ANOVA and spearman rank correlation were used to assess each variable’s independent impact on OHRQoL, while multifactor impact was evaluated by stepwise linear regression. Results: 987 responses were acquired. Higher age caused a higher OHIP-14 score. For prosthesis material, all ceramic presented the lowest OHIP-14 score. For prosthesis type, veneer presented the lowest OHIP-14 score. Either prosthesis service time or SRRS score was positively correlated to OHIP-14 score. In stepwise linear regression, prosthesis material/service time/type and life stress were finally defined as OHRQoL predictors. Conclusion: Three prosthetic characteristics (prosthesis material/service time/type) and life stress are responsible for OHRQoL level of patients treated with anterior FDP.